Ruminococcin-A

CAMPSQ375

Title :

Ruminococcin-A

GenInfo Identifier :

38257917

Source :

Ruminococcus gnavus

Taxonomy :

Bacteria

UniProt:

P83674

PubMed :

11526013

Length :

Activity :

Antibacterial

Gram Nature :

Gram+ve

Target :

Bacteroides vulgatus ATCC 8482 ( MIC =600 microg/ml), Bifidobacterium adolescentis ATCC 15703 ( MIC =150 microg/ml), Bifidobacterium breve ATCC 15700 ( MIC =300 microg/ml), Bifidobacterium catenulatum ATCC 27539 ( MIC =150 microg/ml), B. longum ATCC 15707 ( MIC =75 microg/ml), Eubacterium contortum ATCC 25540 ( MIC =32.5 microg/ml), Ruminococcus obeum ATCC 29174 ( MIC =32.5 microg/ml), R. torques ATCC 27756 ( MIC =300 microg/ml), R. gnavus ATCC 29149 ( MIC =75 microg/ml), C. nexile ATCC 27757 ( MIC =150 microg/ml), C. oroticum ATCC 13619 ( MIC =600 microg/ml), C. perfringens CpA ( MIC =75 microg/ml), C. difficile serogroup A B-1 ( MIC =75 microg/ml), C. difficile serogroup C C253 ( MIC =75 microg/ml), C. difficile serogroup D ATCC 43598 ( MIC =150 microg/ml), C. difficile serogroup F M-1 ( MIC =150 microg/ml), C. difficile serogroup S3 79685 ( MIC =75 microg/ml), C. difficile ATCC 43255 ( MIC =150 microg/ml), C. botulinum type A CIP 38 ( MIC =75 microg/ml), C. botulinum type BNCTC 7273 ( MIC =75 microg/ml), C. botulinum type E NCTC 8266 ( MIC =75 microg/ml), C. sordellii VPI 9048 ( MIC =150 microg/ml), C. bifermentans NCTC 506 ( MIC =75 microg/ml), C. septicum ATCC 12464 ( MIC =150 microg/ml), C. sporogenes ATCC 19404 ( MIC =300 microg/ml), B. cereus Z4222, TZ415 ( MIC =75 microg/ml), B. cereus Z4234, K1231, P2101 ( MIC =150 microg/ml)

Validated :

Experimentally Validated

Comment :

Inactive against B. cereus K1166, L2104, P2174, Z421, P21S , Enterococcus faecalis CIP 76117 , Bacteroides fragilis ATCC 25285 , Bacteroides thetaiotaomicron ATCC 29148 , Bacteroides putredenis ATCC 29800

Pfam :

PF04604 : ( Type-A lantibiotic )

InterPro :

IPR007682 : Lantibiotic_typ-A.

AMP Family :

Bacteriocin

Signature :

ID	Type	Pattern / HMM	T. Length
CAMPBacH27	HMM		27

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	IDA
GO:0019835	Biological Process	Cytolysis	TAS
GO:0050830	Biological Process	Defense response to Gram-positive bacterium	IDA
GO:0006965	Biological Process	Positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria	IDA
GO:0019748	Biological Process	Secondary metabolic process	IEA

Sequence:

GNGVLKTISHECNMNTWQFLF