Esculentin-1

CAMPSQ459

Title :

Esculentin-1

GenInfo Identifier :

416969

Source :

Rana esculenta [Edible frog]

Taxonomy :

Animalia, Amphibians

UniProt:

P32414

PubMed :

8508915

Length :

Activity :

Antibacterial, Antifungal

Gram Nature :

Gram+ve, Gram-ve

Target :

E.coliD21 ( MIC = 0.2 microM), B. megaterrum Bm11 ( MIC = 0.1 microM), S.aureus Cowan1 ( MIC = 0.4 microM), P.aeruginosaATCC15692 ( MIC = 0.7 microM), C.albicans ( MIC = 0.5 microM), S. cerevisiae ( MIC = 0.9 microM)

Hemolytic Activity :

Red blood cells (>100 microM)

Validated :

Experimentally Validated

Pfam :

PF08023 : ( Frog antimicrobial peptide )

InterPro :

IPR012521 : Antimicrobial_frog_2.

AMP Family :

Esculentin

Signature :

ID	Type	Pattern / HMM	T. Length
CAMPEscH	HMM		Variable

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	IDA
GO:0019835	Biological Process	Cytolysis	IEA
GO:0050829	Biological Process	Defense response to Gram-negative bacterium	IDA
GO:0050830	Biological Process	Defense response to Gram-positive bacterium	IDA
GO:0019836	Biological Process	Hemolysis by symbiont of host erythrocytes	IDA

Sequence:

GIFSKLGRKKIKNLLISGLKNVGKEVGMDVVRTGIDIAGCKIKGEC