Cathelicidin-BF antimicrobial peptide

CAMPSQ2303

Title :

GenInfo Identifier :

338817703

Source :

Bungarus fasciatus [banded krait]

Taxonomy :

Animalia, Reptiles

UniProt:

B6D434

PubMed :

18795096

Length :

Activity :

Antibacterial, Antifungal

Gram Nature :

Gram+ve, Gram-ve

Target :

Bacillus subtilis (MIC=9.4microg/ml), Bacillus pumilus (MIC=9.4microg/ml), Bacillus cereus (MIC=1.2microg/ml), Pseudomonas aeruginosa ATCC27853 (MIC=1.2microg/ml), P. aeruginosa (IS, DR) (MIC=2.3microg/ml), P.aeruginosa 08031205(IS, DR) (MIC=9.4microg/ml), P.aeruginosa 08031014(IS, DR) (MIC=18.7microg/ml), Escherichia coliATCC25922 (MIC=2.3microg/ml), E. coli 08A852 (IS, DR) (MIC=1.2microg/ml), E. coli 08A866(IS, DR) (MIC=0.6microg/ml), E. coli 08031017 (IS, DR) (MIC=2.3microg/ml), E. coli 08032813 (IS, DR) (MIC=2.3microg/ml), E. coli 08040726 (IS, DR) (MIC=0.6microg/ml), E. coli 08040722 (IS, DR) (MIC=0.6microg/ml), Staphylococcus aureus ATCC2592 (MIC=4.7microg/ml), S. aureus ATCC25923 (MIC=>400microg/ml), S. aureus 08A865 (IS, DR) (MIC=>400microg/ml), S. aureus 08A875 (IS, DR) (MIC=75microg/ml), S. aureus 08031002 (IS, DR) (MIC=>100microg/ml), S. aureus 08031013 (IS, DR) (MIC=>100microg/ml), S. aureus 08032706 (IS, DR) (MIC=>100microg/ml), S. aureus 08032712 (IS, DR) (MIC=>100microg/ml), S. aureus 08032810 (IS, DR) (MIC=>100microg/ml), Acinetobacter calcoaceticus (MIC=2.3microg/ml), Sphingobacterium siyangense (MIC=9.4microg/ml), Sacharibacillus kuerlensis (MIC=4.7microg/ml), Serratia marcescens SA (MIC=>400microg/ml), Serratia marcescens MA (MIC=>400microg/ml), Pseudomonas luteola (MIC=1.2microg/ml), Salmonella typhi (IS, DR) (MIC=1.2microg/ml), Klebsiella pneumoniae (IS, DR) (MIC=4.7microg/ml), K. pneumoniae 08031012 (IS, DR) (MIC=9.4microg/ml), K. pneumoniae 08040202 (IS, DR) (MIC=0.6microg/ml), K. pneumoniae 08040724 (IS, DR) (MIC=0.3microg/ml), Enterococcus faecium (IS, DR) (MIC=150microg/ml), Aspergillus terreus GIM3.34 (MIC=18.7microg/ml), Aspergillus niculans (MIC=18.7microg/ml), Chaetomium globosum (MIC=37.5microg/ml), Candida albicans ATCC2002 (MIC=4.7microg/ml), Pichia pastoris (MIC=0.3microg/ml)

Hemolytic Activity :

No hemolytic and cytotoxic activity was observed at the dose of up to 400 Ã‚microg/ml.

Validated :

Experimentally Validated

Pfam :

PF00666 : ( Cathelicidin )

InterPro :

IPR001894 : Cathelicidin.

AMP Family :

Cathelicidin

Signature :

ID	Type	Pattern / HMM	T. Length
CAMPCatH	HMM		Variable
CAMPCatH34	HMM		34

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0016020	Cellular Component	Membrane	IEA
GO:0044218	Cellular Component	Other organism cell membrane	IDA
GO:0042742	Biological Process	Defense response to bacterium	IDA
GO:0050832	Biological Process	Defense response to fungus	IDA
GO:0045087	Biological Process	Innate immune response	NAS
GO:0031640	Biological Process	Killing of cells of other organism	IDA

Sequence:

KFFRKLKKSVKKRAKEFFKKPRVIGVSIPF