Temporin-SHf precursor, partial

CAMPSQ2640

Title :

GenInfo Identifier :

295004058

Source :

Pelophylax saharicus [Sahara frog]

Taxonomy :

Animalia, Amphibians

UniProt:

D4YWD1

PubMed :

20308076

Length :

Activity :

Antibacterial, Antifungal

Gram Nature :

Gram+ve, Gram-ve

Target :

E. coli ATCC 25922 (MIC = 25 microM), E. coli ATCC 35218 (MIC >200 microM), E. coli D21 (MIC = 100 microM), E. coli ML-35p (MIC = 30 microM), P. aeruginosa ATCC 27853 (MIC >200 microM), S. aureus ATCC 25923 (MIC = 12.5 microM), E. faecalis ATCC 29212 (MIC = 50 microM), B. megaterium (MIC = 3 microM), C. albicans ATCC 90028 (MIC=50 microM), C. parapsilosis ATCC 22019 (MIC=50 microM), S. cerevisiae (MIC=12.5 microM), A. flavus (MIC>200 microM)

Hemolytic Activity :

Present but temporin-SHf is not cytotoxic against human erythrocytes (LC50 = 200 μm), with a hemolytic activity detected only at peptide concentration far above the MIC values determined for the sensitive strains (3 €“50 μm)

Validated :

Experimentally Validated

Comment :

Also Anti-Protozoan

Pfam :

PF03032 : ( Brevenin/esculentin/gaegurin/rugosin family )

InterPro :

IPR004275 : Brevinin.

AMP Family :

Temporin

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	IEA
GO:0042742	Biological Process	Defense response to bacterium	IEA

Sequence:

FFLSRIFGK