CAMPSQ2738
Title : Human neutrophil peptide-2
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: P59665
PDB: 3HJ2
Structure Database : CAMPST265
PubMed : 15616305
Length : 29
Activity : Antibacterial
Gram Nature : Gram+ve, Gram-ve
Target : E. coli ATCC 8739 ( vLD50 = 3.5 +/- 0.7microg/ml ), E. coli ATCC 25922 ( vLD50 = 3.5 +/- 0.6microg/ml), E. aerogenes ATCC 13048 ( vLD50 = 16 +/- 4.0microg/ml), S. aureus ATCC 25923 ( vLD50 = 4.2 +/- 0.9microg/ml), S. aureus ATCC 29213 ( vLD50 = 2.4 +/- 0.3microg/ml), B. cereus ATCC 10876 ( vLD50 =0.22 ? 0.04microg/ml)
Validated : Experimentally Validated
Pfam : PF00323 : ( Mammalian defensin )
PF00879 : ( Defensin propeptide )
InterPro : IPR016327 : Alpha-defensin.
IPR006080 : Defensin_beta/neutrophil.
IPR002366 : Defensin_propep.
IPR006081 : Mammalian_defensins.
AMP Family : Defensin
Signature :
ID Type Pattern / HMM T. Length
CAMPDefP30 Pattern C-x(4)-C-x(4)-R-[QR]-x-G-T-C-[FIL] 30
CAMPDefH32 HMM 32
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0035578 Cellular Component Azurophil granule lumen TAS
GO:0005576 Cellular Component Extracellular region TAS
GO:0005615 Cellular Component Extracellular space IEA
GO:0005796 Cellular Component Golgi lumen TAS
GO:0006935 Biological Process Chemotaxis TAS
GO:0042742 Biological Process Defense response to bacterium IEA
GO:0050832 Biological Process Defense response to fungus IEA
GO:0051607 Biological Process Defense response to virus IEA
GO:0045087 Biological Process Innate immune response TAS
GO:0031640 Biological Process Killing of cells of other organism IEA
Sequence:
 CYCRIPACIAGERRYGTCIYQGRLWAFCC