CAMPSQ730
Title : Human Defensin-5
GenInfo Identifier : 109156995
Source : Homo sapiens [Human]
Taxonomy : Animalia, Mammals
UniProt: Q01523
PDB: 1ZMP, 3I5W, 4E82, 4E83, 4E86
Structure Database : CAMPST96, CAMPST659, CAMPST316, CAMPST317, CAMPST318
PubMed : 18191790 , 17088326
Length : 32
Activity : Antibacterial, Antifungal, Antiviral
Gram Nature : Gram+ve, Gram-ve
Target : E. coli ATCC 25922 ( IC99 = 49.5 +/- 0.2 microg/ml) , S. aureus ATCC 29123 ( IC99 = 6.3 +/- 1.8 microg/ml) , C. albicans ATCC 99788 amphotericin B resistant ( IC90 > 100 microg/ml ) , Adenovirus
Validated : Experimentally Validated
Pfam : PF00323 : ( Mammalian defensin )
PF00879 : ( Defensin propeptide )
InterPro : IPR016327 : Alpha-defensin.
IPR006080 : Defensin_beta/neutrophil.
IPR002366 : Defensin_propep.
IPR006081 : Mammalian_defensins.
AMP Family : Defensin
Signature :
ID Type Pattern / HMM T. Length
CAMPDefH33 HMM 33
CAMPDefH32 HMM 32
Gene Ontology :
GO ID Ontology Definition
Evidence
GO:0005576 Cellular Component Extracellular region TAS
GO:0005615 Cellular Component Extracellular space IEA
GO:0005796 Cellular Component Golgi lumen TAS
GO:0034774 Cellular Component Secretory granule lumen TAS
GO:0030133 Cellular Component Transport vesicle IEA
GO:0042742 Biological Process Defense response to bacterium IEA
GO:0050832 Biological Process Defense response to fungus IEA
GO:0045087 Biological Process Innate immune response TAS
GO:0031640 Biological Process Killing of cells of other organism IEA
Sequence:
 ATCYCRTGRCATRESLSGVCEISGRLYRLCCR