Human Alpha-Defensin-6

CAMPSQ755

Title :

GenInfo Identifier :

109156999

Source :

Homo sapiens [Human]

Taxonomy :

Animalia, Mammals

UniProt:

Q01524

PDB:

1ZMQ, 3QTE

Structure Database :

CAMPST97, CAMPST296

PubMed :

17088326

Length :

Activity :

Antibacterial

Gram Nature :

Gram+ve

Target :

E. faecium ATCC 1438 ( IC50 = 5.6 +/- 4.0 microg/ml )

Validated :

Experimentally Validated

Comment :

Inactive against E. coli ( IC50 > 100 microg/ml ) , S. aureus ( IC50 > 100 microg/ml ) , C. albicans ATCC 99788 amphotericin B-resistant ( IC90 > 100 microg/ml ) , P. aeruginosa PA01 ( IC50 > 100 microg/ml)

Pfam :

PF00323 : ( Mammalian defensin )
PF00879 : ( Defensin propeptide )

InterPro :

IPR016327 : Alpha-defensin.
IPR006080 : Defensin_beta/neutrophil.
IPR002366 : Defensin_propep.
IPR006081 : Mammalian_defensins.

AMP Family :

Defensin

Signature :

ID	Type	Pattern / HMM	T. Length
CAMPDefH32	HMM		32

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	TAS
GO:0005615	Cellular Component	Extracellular space	IEA
GO:0005796	Cellular Component	Golgi lumen	TAS
GO:0042742	Biological Process	Defense response to bacterium	IEA
GO:0050832	Biological Process	Defense response to fungus	IEA
GO:0045087	Biological Process	Innate immune response	TAS
GO:0031640	Biological Process	Killing of cells of other organism	IEA

Sequence:

AFTCHCRRSCYSTEYSYGTCTVMGINHRFCCL