Spheniscin-2

CAMPSQ885

Title :

Spheniscin-2

GenInfo Identifier :

41019461

Source :

Aptenodytes patagonicus [King penguin]

Taxonomy :

Animalia, Aves

UniProt:

P83430

PDB:

1UT3

Structure Database :

CAMPST647

PubMed :

14525994 , 15123713

Length :

Activity :

Antibacterial, Antifungal

Gram Nature :

Gram+ve, Gram-ve

Target :

M. luteus ( MIC = 1.5-3.0 microM) , B. subtilis ( MIC = 0.8-1.5 microM) , B. cereus ATCC 11778 ( MIC = 3-6 microM) , B. megaterium ( MIC = 0.4-0.8 microM) , S. aureus ( MIC = 1.5-3.0 microM) , S. saprophyticus ( MIC = 1.5-3.0 microM) , S. haemolyticus ( MIC = 1.5-3.0 microM) , N. asteroides ( MIC = 0.8-1.5 microM) , A. viridans ( MIC = 0.4-0.8 microM) , L. monocytogenes ( MIC = 6-12 microM) , E. coli SBS 363 ( MIC = 0.8-1.5 microM) , E. coli 1106 ( MIC = 1.5-3.0 microM) , S. typhimurium ( MIC = 6-12 microM) , K. pneumoniae ( MIC = 50-100 microM) , P. aeruginosa ATCC 82118 ( MIC = 6-12 microM) , V. metshnikovii NCTC 8483 ( MIC = 25-50 microM) , V. anguillarum ATCC 19264 ( MIC = 25-50 microM) , C. glabrata ( MIC > 100 microM) , C. albicans IHEM 8060 ( MIC = 50-100 microM) , C. tropicalis ( MIC = 1.5-3.0 microM) , N. crassa ( MIC = 3-6 microM) , A. fumigatus ( MIC = 3-6 microM)

Validated :

Experimentally Validated

Comment :

Inactive against E. cloacae , A. faecalis

Pfam :

PF00711 : ( Beta defensin )

InterPro :

IPR001855 : Defensin_beta-typ.

AMP Family :

Defensin

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	IEA
GO:0042742	Biological Process	Defense response to bacterium	IEA
GO:0050832	Biological Process	Defense response to fungus	IEA
GO:0031640	Biological Process	Killing of cells of other organism	IEA

Sequence:

SFGLCRLRRGFCARGRCRFPSIPIGRCSRFVQCCRRVW