Hepcidin-25 / LEAP

CAMPSQ983

Title :

Hepcidin-25 / LEAP

GenInfo Identifier :

159162673

Source :

Homo sapiens [Human]

Taxonomy :

Animalia, Mammals

NCBI Taxonomy :

9606

UniProt:

P81172

PDB:

1M4E, 1M4F, 2KEF, 3H0T

Structure Database :

CAMPST37, CAMPST38, CAMPST170, CAMPST263

PubMed :

11034317 , 11113131

Length :

Activity :

Antibacterial, Antifungal

Gram Nature :

Gram+ve, Gram-ve

Target :

E.?coli ML35p, S. epidermidis, S. aureus, C. albicans, group B Streptococcus , Neisseria cinerea , Saccharomyces cerevisiae ( MIC = 50 mg/ml) , B.subtilis ( MIC = 40 mg/ml )

Validated :

Experimentally Validated

Comment :

Inactive against Pseudomonas aeruginosa , Rhodotorula rubra , Escherichia coli BL21 , Pseudomonas fluorescens

Pfam :

PF06446 : ( Hepcidin )

InterPro :

IPR010500 : Hepcidin.

AMP Family :

Hepcidin

Signature :

ID	Type	Pattern / HMM	T. Length
CAMPHepH	HMM		Variable

Gene Ontology :

GO ID	Ontology	Definition	Evidence
GO:0005576	Cellular Component	Extracellular region	NAS
GO:0006879	Biological Process	Cellular iron ion homeostasis	IEA
GO:0042742	Biological Process	Defense response to bacterium	IEA
GO:0050832	Biological Process	Defense response to fungus	IEA
GO:0006955	Biological Process	Immune response	TAS
GO:0031640	Biological Process	Killing of cells of other organism	IEA

Sequence:

DTHFPICIFCCGCCHRSKCGMCCKT